Changes of serum autoantibodies against ?_1 and M_2 receptors in the patients of obstructive sleep apnea syndrome with chronic obstructive pulmonary disease / 中国病理生理杂志

ABSTRACT

AIM: To study the changes of serum autoantibodies against ? 1- adrenergic and M 2-muscarinic receptors in obstructive sleep apnea syndrome (OSAS) patients with chronic obstructive pulmonary disease (COPD), that is, overlap syndrome (OS). METHOD: Serum autoantibodies against ? 1 and M 2 receptors in 26 cases with OS, 32 with OSAS, 30 with COPD and 28 normal subjects were determined by using enzyme-linked immunosorbent assay(ELISA). RESULTS: The positive rates and titer of ? 1 and M 2 receptor autoantibodies are significantly increased in OS group (92.2%,57.7% and 1∶98, 1∶67), compared to OSAS (71.9%, 40.6% and 1∶83, 1∶30) or COPD group (70.0%, 36.7% and 1∶79, 1∶28) (P