The protective effect of preconditioning on rabbit liver during ischemia and reperfusion and its potential mechanism / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)1986.
Artigo
em Chinês
| WPRIM
| ID: wpr-516937
ABSTRACT
AIM:
To investigate the protective effect of preconditioning on rabbit liver during total ischemia and reperfusion and its mechanism.METHODS:
Using hepatic ischemia and reperfusion injury (HIRI) model in rabbits, animals were randomly divided into three groups control group (A), non-preconditioning group(B) and preconditioning group(C), different effects of preconditioning on several parameters including alanine aminotransferase (ALT) activity and levels of nitric oxide (NO) and malondialdehyde (MDA) in plasma or liver tissue as well as hepatocellular morphological changes were measured and observed during HIRI.RESULTS:
In C group NO levels of plasma and liver tissue were higher than those in B group (P0.05); abnormal morphological chages of liver cells in A group were ameliorated remarkably too during HIRI.CONCLUSION:
Preconditioning can attenuate HIRI by improving NO level and reducing oxygen free radicals level.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Pathophysiology
Ano de publicação:
1986
Tipo de documento:
Artigo
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