Characteristics of energy metabolism in brain mitochondria of rats exposed to hypoxia / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)2000.
Artigo
em Chinês
| WPRIM
| ID: wpr-517159
ABSTRACT
AIM:
To explore the characteristics of energy metabolism in brain mitochondria of rats exposed to acute and chronic hypoxia.METHODS:
Animal grouping Wistar rats were randomized into acute hypoxic group (AH), chronic hypoxic group (CH) and the control. Respiratory function, F 0F 1-ATPase activity, mitochondrial ATP, ADP and AMP contents and ATP production rate were measured respectively.RESULTS:
In AH, brain mitochondrial respiratory state IV (ST 4) was increased, while respiratory control rate (RCR), mitochondrial ATP content, ATP production rate and F 0F 1-ATPase activity were decreased respectively. In CH, ST 4, RCR, mitochondrial ATP content and F 0F 1-ATPase activity were reversed partially.CONCLUSION:
Acute hypoxia may impair brain mitochondria energy metabolism by way of depressing mitochondrial oxidative phosphorylation and ATP production and these parameters gain partial reablement during chronic hypoxia.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Chinês
Revista:
Chinese Journal of Pathophysiology
Ano de publicação:
2000
Tipo de documento:
Artigo
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