Studies on Relationship of Hepatitis B Virus DNA Quantity and Transmission from Mothers to Infants / 中华围产医学杂志

ABSTRACT

s Objective To study the effect of HBV DNA of pregnant mothers on HBV intrauterine transmission. Methods Thirty one pairs of mothers and their newborn babies were detected for HBV by the HBV DNA qualitative PCR and HBV serology, as well as the concentration of HBV DNA in the blood by fluorescence quantitative PCR. Results There was a positive linear regression( r=0.5401, P=0.0017 ) between the concentration of HBV DNA in the infant and that in the mothers. Among the 31 infants, 19 showed abnormal by HBV DNA qualitative PCR and(or) HBV serology. It indicated that there was vertical transmission from the mothers to their infants. The transmission rate is 61%. The concentration of HBV DNA copies/ml(7.2?3.1) in mothers whose infants were abnormal was significantly higher than the others(5.8?1.3). Among the 31 mothers, 6 cases showed anti-HB positive and their babies were of much lower concentration of HBV DNA(4.2?1.8) than others(6.1?1.8). Conclusion The quantity of HBV in mothers reflected the strength of HBV vertical transmission and the chance of HBV transmission from mothers to infants have been decreased after mothers have obtained HbsAb.