Inhibition of ICAM-1 expression on endothelial cells in hypoxia/reoxygenation by antisense oligodeoxynucleotides / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)2000.
Artigo
em Chinês
| WPRIM
| ID: wpr-517293
ABSTRACT
AIM:
To investigate the effect of antisense oligodeoxynucleotides (AS-ODN) on the intercellsular adhesion molecule-1(ICAM-1) expression on endothelial cells in hypoxia/reoxygenation(H/R).METHODS:
With cultured glomerular vascular endothelial cell in H/R,the positive percentage of ICAM-1 expression was measured by flow cytometry before and after giving AS-ODN.RESULTS:
The ICAM-1 expression did not increase on glomerular vascular endothelial cell in 10 hours hypoxia compared to control group,it increased in 6 hours reoxygenation, and decreased by 40.6% after giving AS-OND.CONCLUSION:
AS-ODN may decrease the expression of ICAM-1 on endothelial cells in H/R.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Pathophysiology
Ano de publicação:
2000
Tipo de documento:
Artigo
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