Restricted expansion of T cell receptor (TCR)V? genes in leukemic patients subjected to allogeneic hematopoeitic stem cell transplantation / 中国病理生理杂志

ABSTRACT

AIM: To investigate restricted expansion of TCR V? gene repertoire in patients with leukemia following allogeneic hematopoietic stem cell transplantation. METHODS: TCR V? subfamily genes in peripheral blood mononuclear cells from 7 cases of leukemia was amplified using RT-PCR. RESULTS: Only two-eight fragments of V? genes were detected in samples from these patients, and the detected fragments are different in different patients. CONCLUSION: TCR complexes were abnormal in all patients, part of the genes were seletively expansed and part of them were suppressed after transplantation.