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Prenatal Cytogenetic Diagnosis with Fetal Ascitic Fluid as a Rapid Chromosome Analysis / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology ; : 2997-3000, 1998.
Artigo em Coreano | WPRIM | ID: wpr-51842
ABSTRACT

OBJECTIVE:

The goal of this study is to determine the efficacy of rapid karyotyping from fetal ascitic fluid.

METHODS:

In three cases of isolated fetal ascites diagnosed by prenatal ultrasonography, ultrasound guided fetal paracentesis and amniocentesis were performed and successfully obtained. Fetal karyotyping in each case at 29, 30 and 32 weeks gestation using modified lymphocyte culture method was conducted.

RESULTS:

The chromosomal analysis was successful within 72 hours and abnormalities were detected in two cases and revealed trisomy 21 in each case. Our study demonstrated that the majority distribution of white blood cells was lymphocytes which ranged from 2.1 * 10(6) cells/ml to 3.7 * 10(6) cells/ml and the cell density for culture was at least than 0.35 * 10(6) cells/ml.

CONCLUSION:

The use of ascitic fluid as a cell source to achieve rapid fetal karyotyping can be valuable when cordocenteis or amniocentesis would be technically more difficult, or when rapid result is required for planning of perinatal management at late second or third trimester gestational age.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Terceiro Trimestre da Gravidez / Ascite / Líquido Ascítico / Linfócitos / Contagem de Células / Ultrassonografia Pré-Natal / Ultrassonografia / Idade Gestacional / Síndrome de Down / Paracentese Tipo de estudo: Estudo diagnóstico Limite: Feminino / Humanos / Gravidez Idioma: Coreano Revista: Korean Journal of Obstetrics and Gynecology Ano de publicação: 1998 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Terceiro Trimestre da Gravidez / Ascite / Líquido Ascítico / Linfócitos / Contagem de Células / Ultrassonografia Pré-Natal / Ultrassonografia / Idade Gestacional / Síndrome de Down / Paracentese Tipo de estudo: Estudo diagnóstico Limite: Feminino / Humanos / Gravidez Idioma: Coreano Revista: Korean Journal of Obstetrics and Gynecology Ano de publicação: 1998 Tipo de documento: Artigo