Effect of Combined Treatment of Steroid and Angiotensin II Receptor Blocker (ARB) in Proteinuric IgA Nephropathy / 대한신장학회잡지
Korean Journal of Nephrology
;
: 539-545, 2003.
Artigo
em Coreano
| WPRIM
| ID: wpr-51858
ABSTRACT
BACKGROUND:
It has been reported that prednisolone (PDL) therapy favorably influences proteinuria and renal function in the patients with IgAN in whom ARB as well as ACE inhibitor has an anti- proteinuric effect. Therefore, we did a controlled prospective trial to test the effect of treatment with PDL (daily high-dose for 6 months) and ARB in proteinuric adult patients with IgAN.METHODS:
Forty-two patients with proteinuria > or =1.0 g/day and serum Cr < or =2.0 mg/dL were randomized to treatment with PDL and ARB and to that with ARB alone.RESULTS:
The follow-up period lasted 15.4+/-3.5 months in combination group (n=18) and 19.8+/-7.4 months in ARB group (n=20). Proteinuria was significantly reduced in the both groups (ARB group from 4.31+/-2.85 g to 1.38+/-1.09 g vs. combination group from 4.67+/-5.33g to 0.78+/-0.99 g). The rate of complete remission was 10% in ARB group and 44% in combination group at the final follow-up (p<0.05). There were no differences of mean serum Cr between groups before and after treatment. The number of patient with aggravation in renal function was five (25%) in ARB group and one (5%) in combination group.CONCLUSION:
This study shows that the urinary protein excretion was effectively reduced by both groups and the rate of complete remission was higher in combination group than in ARB group. Long- term follow-up may be helpful to define the effect on the renal function in IgAN patients.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Proteinúria
/
Imunoglobulina A
/
Angiotensina II
/
Angiotensinas
/
Prednisolona
/
Receptores de Angiotensina
/
Estudos Prospectivos
/
Seguimentos
/
Glomerulonefrite por IGA
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo observacional
/
Estudo prognóstico
Limite:
Adulto
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Nephrology
Ano de publicação:
2003
Tipo de documento:
Artigo
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