Effect of esmolol on beta-adrenoceptor desensitization during cardiac surgery / 中华麻醉学杂志

ABSTRACT

II degree, severe liver/kidney function abnormality, diabetes, hypertension, thyroid disease or blood diseases were also excluded. Anesthesia was induced with midazolam 0. 1mg?kg-1, fentanyl 10?g?kg-1 and vecuronium 0.15 mg?kg-1 and maintained with midazolam and fentanyl. In group E esmolol was infused first at rate of 500?g?kg-1 ? min-1 for 4 min, then the infusion was continued at a slower rate of 200?g?kg-1? min-1 until 10 min after aortic declamping. In group C Ringer's solution was infused instead of esmolol. Radial artery and right internal jugular vein were cannulated and BP, HR, CVP were monitored during operation. Arterial and right atrial blood was obtained for blood gas analysis and central venous oxygen saturation ( ScvO2) was recorded before heparinization and 30 min after CPB was terminated. Dopamine/sodium nitroprusside (DA/SNP) ratio was calculated after CPB when blood pressure was stable. In addition, arterial blood samples were taken at the time of heparinizaion (T1), 10 min (T2 ) and 60 min (T3 ) after aortic declamping for determination of cAMP content in isoproterenol-stimulated lymphocytes. Results The DA/SNP ratio was significantly higher in group C than in group E (P