Clinical Observation of the Application of Nicardipine in Direct Laryngoscopy / 中国药房

ABSTRACT

OBJECTIVE:To assess the preventing effect of nicardipine on stress reaction induced by direct laryngoscopy.ME_THODS30 patients undergoing elective direct laryngoscopy were randomly divided into two groupsthe routine group(group C)and nicardipine group(group N),15 patients for each group.In group C,anesthesia was performed with routine anesthetics,in group N,addition to routine anesthetics,nicardipine was administered by a bolus of 10?g/kg,there after 1～2?g/(kg?min)continuously intravenous administration.Blood pressure(BP),heart rate (HR) and blood sugar(Glu)were recorded perioperatively.RESULTS:The BP and HR increased in both groups from intubation to extubation,but when compared to the base value,the increase in group C had statistical significance (P0.05);There were significant differences between two groups at the same time points(P