Relationship between absence of expression of DPC4/SMAD4 gene and pathogenesis of pancreatic carcinoma / 中国普通外科杂志
Chinese Journal of General Surgery
;
(12)1993.
Artigo
em Chinês
| WPRIM
| ID: wpr-518856
ABSTRACT
Objective To review the relationship between absence of expression of DPC4/SMAD4 gene and pathogenesis of pancreatic carcinoma(PC). Methods A summerized paper was made on the review of relative literatures. Results and Conclusions A new gene DPC4 (located on chromosome 18q21.1 region) has been identified as a candidate tumor suppression gene. SMAD4 belongs to the evolutionarily conserved family of SMADs proteins that are crucial intracellular mediators of signals from the transforming growth factor ?(TGF-?). In TGF-? super family signal pathways, SMAD4 plays a pivotal role .There is a close relationship between absence of expression of DPC4 gene and pathogenesis of pancreatic carcinoma.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
Idioma:
Chinês
Revista:
Chinese Journal of General Surgery
Ano de publicação:
1993
Tipo de documento:
Artigo
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