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Relationship between absence of expression of DPC4/SMAD4 gene and pathogenesis of pancreatic carcinoma / 中国普通外科杂志
Chinese Journal of General Surgery ; (12)1993.
Artigo em Chinês | WPRIM | ID: wpr-518856
ABSTRACT
Objective To review the relationship between absence of expression of DPC4/SMAD4 gene and pathogenesis of pancreatic carcinoma(PC). Methods A summerized paper was made on the review of relative literatures. Results and Conclusions A new gene DPC4 (located on chromosome 18q21.1 region) has been identified as a candidate tumor suppression gene. SMAD4 belongs to the evolutionarily conserved family of SMADs proteins that are crucial intracellular mediators of signals from the transforming growth factor ?(TGF-?). In TGF-? super family signal pathways, SMAD4 plays a pivotal role .There is a close relationship between absence of expression of DPC4 gene and pathogenesis of pancreatic carcinoma.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo de etiologia / Estudo prognóstico Idioma: Chinês Revista: Chinese Journal of General Surgery Ano de publicação: 1993 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo de etiologia / Estudo prognóstico Idioma: Chinês Revista: Chinese Journal of General Surgery Ano de publicação: 1993 Tipo de documento: Artigo