Determination of the Content of Meropenem and Observation of the Stability of Meropenem in Mixing With Infusion Fluids / 中国药房
China Pharmacy
;
(12)1991.
Artigo
em Chinês
| WPRIM
| ID: wpr-519041
ABSTRACT
OBJECTIVE:
To establish a HPLC method for determining the content of Meropenem and to observe the stability of Meropenem in mixing with 5%GS,GNS and NS.METHODS:
The conditions of HPLC werecolumn,Nova-Pak C18;mobile phase,acetonitrile-0.05mol KH2PO4(4∶96);flow rate,1.0ml/min;detection wavelength,300nm.After Meropenem mixing with 5%GS,GNS and NS,the changes of external apperance were observed in room temperature,the content was detected with HPLC and the pH and insoluble particles were determined.RESULTS:
The calibration curve was in good linearity in the range of 12.5~250?g/ml(r=0.9 999)and the recovery was 99.7% with RSD=1.1%.CONCLUSION:
This detection method is effective,rapid and accurate.Meropenem is stable in infusion fluids for 4 hr.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
1991
Tipo de documento:
Artigo
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