Investigation on the Dissolubilities of Tamoxifen Citrate Tablets Produced by Four Different Factories / 中国药房

ABSTRACT

OBJECTIVE:To compare the dissolubilities of Tamoxifen citrate tablets from four domestic pharmaceutical factories METHODS:Rotating basket method and paddle method were used,and Td were calculated by Weibull distribution RESULTS:Statistical analysis showed that there were significant differences in Td among the products from different factories,and the dissolubility of the same product detected by rotating basket was slower than that by paddle method CONCLUSION:The dissolubilities of Tamoxifen citrate tablets have significant differences among four different domestic products