Experiment Study on the Quality Standard and Formulation Screening of Bergenin Tablets / 中国药房

ABSTRACT

OBJECTIVE:To screen the optimum formulation of bergenin tablet and to establish an analysis method for measuring the content of bergenin in the tablets METHODS:The L3(34) orthogonal table and the parameter of in vitro dissolubility(Td) was employed to select the optimum formulation by taking LS-HPC,tween-80-starch,and starch as the three main factors,and three levels were adopted for each-factor The dual-wavelength spectrophotography was employed to determine the content of bergenin in the tablets RESULTS:The experimental results indicated that LS-HPC and tween-80-starch were the chief factors of influencing dissolution of tablet(P0 05) The optimum formulation was composed of bergenin:0 125g,Ls-HPC:0 0 186g,tween 80-starch:0 0 248g,starch:0 1 354g,magnesium stearate:0 0 032g The dual-wavelength spectrophotography was convenient and accurate The average recovery rate of bergenin was (100 92?0 87)%(n=8) CONCLUSION:The formulation has merits of low price of supplementary materials,rapid release of effective component,simple manufacture technique,and stability in quality