Study on the Compatible Stability of Ciprofloxacin Lactate Injection With Metronidazole in Glucose Injection / 中国药房
China Pharmacy
;
(12)2001.
Artigo
em Chinês
| WPRIM
| ID: wpr-519430
ABSTRACT
OBJECTIVE:
To study the stability of mixture of ciprofloxacin injection and metronidazole in glucose injection at high temperature(50℃~70℃)and at room temperature((20?1)℃)storageMETHODS:
UV-spectrophotometry method was used for determining the contents of ciprofloxacin and metronidazole The changes in the content,pH value and appearance were observed by classical constant-temperature experiment and room temperature storageRESULTS:
The linearity ranges for ciprofloxacin and metronidazole were 1 00~10 02?g/ml and 2 01~20 08?g/ml;the average recoveries were(101 30?4 28)% and(99 58?1 63)%,respectively The heat decomposition products at 70℃ for 8 hours did not interfere with the assay The relative contents of ciprofloxacin and metronidazole were more than 95% and there were no significant changes of the pH value and the color with accelerating experiment for 8 hours at 50℃~70℃ and for 120 hours at (20?1)℃CONCLUSION:
We found that admixture of ciprofloxacin with metronidazole in glucose solution was stable at high temperature for 8 hours and at room temperature for 120 hours Ciprofloxacin injection was compatible with metronidazole in glucose injection
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2001
Tipo de documento:
Artigo
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