Effects of exogenous thyroid hormone on intestinal barrier in sepsis / 中国普通外科杂志

ABSTRACT

ObjectiveTo investigate the relationship between metabolic abnormalies of thyroid hormone and intestinal barrier disfunction and the potential protective effects of exogenous thyroid hormone in sepsis. MethodsMurine septic model was established through cecal ligation puncture. Triiodothyronine (15??g/kg) was given to the septic rats to correct the low T 3 syndrome. ResultsThere was significant negative correlation between the seral concentration of free T 3 or free T 4 and MDA concentration in the tissues of small intestines. The insulting degree of the intestinal barrier in the treatment group were much milder than that of the sepsis group. ConclusionsThere were significant correlation between the metabolic abnormalies of thyroid hormone and the oxic insults of the intestinal barriers in sepsis. Providing the thyroid hormone for the septic rats could protect the intestinal barriers and improve the prognosis of sepsis.