Alterations in Peyer's patches lymphocytes following surgery/antibiotics administration and the effects of probiotics in rats / 中国普通外科杂志

ABSTRACT

ObjectiveThis study was to investigate the effects of surgery and antibiotics on sub-type of lymphocytes and bowel microecology, and the possible beneficial effects of probiotics in protecting gut associated lymphoid tissue(GALT). Methods Male SD rats were subjected to receive gastrostomy and small bowel resection with or without treatment of antibiotics or antibiotics plus lactobacillus plantarum 299v postoperatively for a week. Each group consists of 6 rats. ResultsSurgery and antibiotics significantly reduced the total amount of lymphocytes especially the B cell and CD8 +T cell subtypes in Peyer′s patches(PP), and destroyed the microflora balance. Probiotics protect PP lymphocytes. Conclusions This study found the alteration in lymphocytes sub-types in PP following GI surgery and antibiotics administration. Probiotics has protective effects on GALT composition.