Inhibitory ?-adrenergic receptor in heart / 中国病理生理杂志

ABSTRACT

adrenergic receptor is the third subtype of ?-adrenergic receptors. The genetic structure and pharmacological property of ? 3-adrenergic receptor are markedly distinguished from ? 1-and ? 2-adrenergic receptor subtypes. Recently studies show that myocardial ? 3-adrenergic receptor mediates negative inotropic effect through Gi-protein/NO/cGMP pathway, the expression of ? 3-adrenergic receptor and negative inotropic effect mediated by ? 3-adrenergic receptor are increased in heart failure. However, because of the low expression of ? 3-adrenergic receptor in the heart, the actual pathophysiological significance of ? 3-adrenergic receptor remains unknown.