Determination of the Contents of the Main Components in Co-tinidazole Gargle by HPLC / 中国药房
China Pharmacy
;
(12)1991.
Artigo
em Chinês
| WPRIM
| ID: wpr-520754
ABSTRACT
OBJECTIVE:
To develop a HPLC method for determination of tinidazole and chlorhexidine acetate in co-tinidazole gargle.METHODS:
Tinidazole and chlorhexidine acetate in co-tinidazole gargle were determined by RP-HPLC with metronidazole as the internal standard.ODS was adopted as stationary phase and acetonitrile-water(35∶65)as mobile phase.The detector was operated at UV254nm.RESULTS:
The calibration curve of tinidazole was linear within the concen?tration range of(0.01~0.10)mg/ml(r=0.9999);The calibration curve of chlorhexidine acetate was linear within the con?centration range of(0.01~0.10)mg/ml(r=0.9997).The average recoveries of tinidazole and chlorhexidine were(97.06~102.02)%and(97.21~103.40)%,respectively.The within-day coefficients of variance were(0.20~1.26)%and(0.71~1.11)%,respectively.The between-days coefficients of variance were(0.50~2.06)%and(0.80~2.17)%,respective?ly.CONCLUSION:
The method is suitable for determination of preparations containing tinidazole and chlorhexidine acetate.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
1991
Tipo de documento:
Artigo
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