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The Percutaneous Permeability of Methoxypsoralen Liposomal Gel / 中国药房
China Pharmacy ; (12)2001.
Artigo em Chinês | WPRIM | ID: wpr-521624
ABSTRACT

OBJECTIVE:

To study the percutaneous permeability of methoxypsoralen liposomal gel

METHODS:

The preparations were applied on the rat skin in vitro and in vivo with common gel and Mingbailing tincture as control,and the drug concentrations in the receiver,skin,blood and other organs were determined by RP-HPLC

RESULTS:

In vitro experiment,liposomal gel showed the lowest percutaneous permeation rate and the highest retention in skin In vivo studies illuminated that the skin depositions of drug encapsulated in liposome was(4 37?0 91) and (3 36?0 58) times those of the common gel and tincture respectively

CONCLUSION:

Methoxypsoralen liposomal gel showed an evident targeting effect on skin

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: China Pharmacy Ano de publicação: 2001 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: China Pharmacy Ano de publicação: 2001 Tipo de documento: Artigo