Expression of NOS in the rat colorectal carcinoma cells / 中国普通外科杂志

ABSTRACT

Objective To study the expression of nitric oxide synthase (NOS) during the development of rat colorectal carcinoma. Methods Rat colon carcinoma was induced by injection of 1,2- dimethylhydrazine (1,2-DMH).The expression of eNOS, nNOS and iNOS in normal colon mucosa and colorectal carcinoma was observed by immunohistochemistry. ResultseNOS and nNOS were expressed in normal mucosa. Neither eNOS nor nNOS alterations were observed in carcinoma tissues,iNOS expression was very strong in carcinoma samples(87%)and only 10% in normal colon mucosa. ConclusionOur results show that iNOS may play an important role in the 1,2-DMH induced colon tumorigenesis.