Comparison of the Effect of Preoperative Acute Hypervolemic Hemodilution and Normovolemic Hemodilution in Patients Undergoing Hepatic Tumor Operation / 中国医师杂志

ABSTRACT

Objective To compare the effect of acute hypervolemic hemodilution (AHH) and normovolemic hemodilution (ANH) as means of perioperative blood conservation in the patients undergoing hepatic tumor operation. Methods 45 ASA I-II patients with hepatic tumor were randomly divided into three groups, control, AHH and ANH, each group containing 15 cases. After induction of anesthesia, the patients of AHH group were rapidly infused 20 ml/kg fluid intravenously, the patients of ANH group were withdrawn 15ml/kg intravenous blood and simultaneously infused the same volumes of 6% hydroxyethyl starch. BP, HR, ECG, SaO2, urine output, fluid input and blood loss were monitored during operation. Blood samples were collected before and after hemodilution, at end of operation and the first day of postoperation to measure Hb, Hct, Plt, blood biochemical indices, PT and APTT. Results After hypervolemic and normovolemic hemodilution Hct reduced to 30.9?3.3% and 29.6?2.8% from 39.8?3.4% and 40.2?3.5% respectively, and PT and APTT were significantly prolonged in both the AHH and ANH patients (P