Simultaneous Determination of Metronidazole and Chloramphenicol in Comedo Cream by HPLC / 中国药房
China Pharmacy
;
(12)1991.
Artigo
em Chinês
| WPRIM
| ID: wpr-522472
ABSTRACT
OBJECTIVE:
To establish a HPLC method for simultaneous determination of metronidazole and chloram. phcnicol in comedo cream.METHODS:
The method included a Diamonsil C18 column (250mm ? 4.6mm, 5?m) and methanol water(50 50,v/v)as the mobile phase and an ultraviolet detecting wavelength of 280nm .RESULTS:
The calibralion curve was linear in a concentration range of ( 10 - 250)?g/ml of both metronidazole and chloramphenicol (r = 0.9 998) .The average recoveries of metronidazole and chloramphenicol were 100.53% , 100.53% and RSD were 0.79% , 0.56% respectively .CONCLUSION:
The method for the determination of metronidazole and chloramphenicol was rapid and convenient. It can be used for the quality control of metronidazole and chloramphenicol in cream.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
1991
Tipo de documento:
Artigo
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