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Effects of thymosin ?_1 on the development and maturation of thymocytes / 中国病理生理杂志
Article em Zh | WPRIM | ID: wpr-522754
Biblioteca responsável: WPRO
ABSTRACT
AIM: To investigate the effect of Thymosin ? 1 on the development and matutation of thymocytes. METHODS: The proportion of CD4+CD8+ thymocytes and the expression of smoothened (Smo) of the hedgehog (Hh)-signaling in CD4-CD8-thymocytes were examined to observe the effect of thymosin ? 1 on thymocyte development and matutation. RESULTS: Flowcytometric analysis showed that thymosin ? 1 showed activity at a low dose of 30 ?g/kg, and 30 ?g/kg thymosin ? 1 accelerated the replenishment and maturation of thymocytes according to the expression of Smo of the Hh-signaling in CD4-CD8-thymocytes, the potent negative regulator of proliferative responses. CONCLUSION: Thymosin ? 1 can accelerate thymocyte development from CD4-CD8- to CD4+CD8+.
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Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Chinese Journal of Pathophysiology Ano de publicação: 1989 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Chinese Journal of Pathophysiology Ano de publicação: 1989 Tipo de documento: Article