The Expression of Folate Sensitive Fragile Sites in Patients with Bipolar Disorder
Yonsei Medical Journal
;
: 137-141, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-52281
ABSTRACT
PURPOSE:
Genetic factors are known to be important in the etiology of bipolar disorder (BD). The fragile sites (FSs) are a very interesting subject for the study of clinical disorders. The aim of this study was to evaluate fragile sites seen in patients with bipolar disorder and find a correlation between some fragile sites and bipolar disorder. PATIENTS ANDMETHODS:
The frequencies of folate sensitive FSs were compared in short-term whole blood cultures from bipolar patients and from normal individuals.RESULTS:
The rate of FS expression in the patients was considerably higher than in the controls (p < 0.001). Several chromosome regions including 1p36, 1q21, 1q32, 3p25, 7q22, 7q32, 11q23, 12q24, 13q32, 14q24, Xp22 and Xq26 were represented considerably more often in the patients than in the controls (p value between 0.001 to 0.036). Among these FSs, the sites 1p36, 1q21, 3p25, 7q22, 7q32, and 14q24 were not observed in other studies.CONCLUSION:
These regions can be the most active of hot spots in the genomes of bipolar patients, and may harbor important genes associated with BD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transtorno Bipolar
/
Fragilidade Cromossômica
/
Cromossomos Humanos
/
Predisposição Genética para Doença
/
Citogenética
/
Sítios Frágeis do Cromossomo
/
Ácido Fólico
Tipo de estudo:
Estudo diagnóstico
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Yonsei Medical Journal
Ano de publicação:
2009
Tipo de documento:
Artigo
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