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Grape seed polyphenols reverses multidrug resistance of human breast cancer / 中国普通外科杂志
Chinese Journal of General Surgery ; (12)2001.
Artigo em Chinês | WPRIM | ID: wpr-523067
ABSTRACT
Objective To explore if grape seed polyphenols (GSP) reverses human breast cancer multidrug resistance. MethodsIn this study,adriamycin-resistant human breast carcinoma cells ( MCF-7/ADR ) and its parental cells (MCF-7) were used to determine the effect of GSP. MTT assay was adopted to evaluate the cytotoxity. Western blot and Northern blot were performed to observe the expression of MDR1 in MCF-7/ADR. Adriamycin accumulation was measured by flow cytometry (FCM). ResultsGSP ( 1.2 mg/L ,2.4 mg/L) inhibited the expression of P-gp to 80.83%( t =5.58,P

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of General Surgery Ano de publicação: 2001 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of General Surgery Ano de publicação: 2001 Tipo de documento: Artigo