Effect of 1 mg of prophylactic haloperidol for postoperative nausea and vomiting after gynecological laparoscopic surgery using IV patient controlled analgesia
Anesthesia and Pain Medicine
; : 30-34, 2010.
Article
em Ko
| WPRIM
| ID: wpr-52307
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Haloperidol, a major tranquilizer similar to droperidol, has been found to have a potent antiemetic effect on postoperative nausea and vomiting (PONV), but the supporting evidence was incomplete, especially in Korea.Therefore we evaluated the prophylactic effect of haloperidol on opioid-based IV patient-controlled analgesia (PCA) related PONV in susceptible patients after gynecological laparoscopic surgery. METHODS: Ninety-six adult women scheduled gynecological laparoscopic surgery were enrolled in a randomized, double-blinded and placebo study.Patients received haloperidol 1 mg (Group H) or saline (Group C) 30 min before the end of surgery.Fentanyl-based IV PCA was administered after surgery.The incidences and severity of nausea, vomiting, rescue antiemetic administration, pain, and adverse effects (cardiac arrhythmias and extrapyramidal effects) were assessed for 24 h after surgery.The sedation score was recorded in the post-anesthesia care unit for 2 h. RESULTS: The incidences and severity of nausea and the number of antiemetic administration were significantly lower in Group H than Group C (P < 0.05). But the sedation and pain score were similar. There was no QTc prolongation or extrapyramidal symptom in both groups. CONCLUSIONS: Prophylactic haloperidol 1 mg is effective in preventing PONV related to fentanyl-based IV PCA, with less adverse effects, in patients undergoing gynecological laparoscopic surgery.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Arritmias Cardíacas
/
Vômito
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Anafilaxia Cutânea Passiva
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Incidência
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Analgesia Controlada pelo Paciente
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Laparoscopia
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Náusea e Vômito Pós-Operatórios
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Droperidol
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Haloperidol
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Antieméticos
Tipo de estudo:
Clinical_trials
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Incidence_studies
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Prognostic_studies
Limite:
Adult
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Female
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Humans
Idioma:
Ko
Revista:
Anesthesia and Pain Medicine
Ano de publicação:
2010
Tipo de documento:
Article