A new acute pancreatitis mice model / 中国普通外科杂志
Chinese Journal of General Surgery
;
(12)2001.
Artigo
em Chinês
| WPRIM
| ID: wpr-523335
ABSTRACT
Objective To develop a new severe but sublethal acute pancreatitis mice model. Methods The animals were divided into two groups the bile acid injection group and the control group. In the bile acid injection group, acute necrotizing pancreatitis was induced by intraductal administration of 0.1 ml of 1.0 % bile acid under 30 cm H 2O pressure, while the controls underwent the sham operation. The structural and functional features of the pancreas were examined at 24 hours after surgery. Results Pancreatic edema, bleeding, acinar cell necrosis and inflammation accompanied with increased serum amylase and MPO were found in the bile acid injection animals. Conclusions The sublethal acute pancreatitis mice model is ideal for pathogenetic and therapeutic study of acute necrotizing pancreatitis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of General Surgery
Ano de publicação:
2001
Tipo de documento:
Artigo
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