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Effects of hemorrhagic shock on BK_(Ca) channel tyrosine phosphorylation level in mesenteric artery in rats / 中国病理生理杂志
Chinese Journal of Pathophysiology ; (12)2000.
Artigo em Chinês | WPRIM | ID: wpr-523824
ABSTRACT

AIM:

To study the effects of hemorrhagic shock on BK Ca channel tyrosine phosphorylation in rat superior mesenteric artery and the role of nitric oxide (NO) in BK Ca channel tyrosine phosphorylation.

METHODS:

The hemorrhagic shock model [(35?5) mmHg] was established in rats and the whole lysate of superior mesenteric artery were extracted and analyzed by immune precipition (IP) and immunoblotting. The tyrosine phosphorylation levels of BK Ca channel alpha-subunit in mesenteric artery in hemorrhagic shock rats were investigated, and the modulation of BK Ca channel alpha-subunit tyrosine phosphorylation by NO and its dose-and time-dependended relationships were observed.

RESULTS:

The tyrosine phosphorylation level of BK Ca channel alpha-subunit in mesenteric artery in rats increased significantly after hemorrhagic shock 2 h and 4 h (P

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Pathophysiology Ano de publicação: 2000 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Pathophysiology Ano de publicação: 2000 Tipo de documento: Artigo