Effect of Calcium Dobesilate on Renal Oxidative Stress in Type2 Diabetic Rats / 中国药房
China Pharmacy
;
(12)2001.
Artigo
em Chinês
| WPRIM
| ID: wpr-523868
ABSTRACT
OBJECTIVE:
To evaluate effect of calcium dobesilate on renal oxidative stress in type2diabetic rats.METHODS:
30rats were divided into3groups of normal rats,diabetic rats,diabetic rats treated with calcium dobesi?late.Content of malonaldehyde(MDA)and activity of antioxidant enzymes including superoxide dismutase(SOD),glutathione peroxidase(GSH-PX)in the renal tissue were compared among the groups.In addition,blood glucose,serum creatinine(Cr),blood urea nitrogen(BUN)were measured;the renal tissue were observed by light microscopy and electron microscopy.RESU_ LTSCompared with untreated group,the level of BUN,Cr,renal MDA in calcium dobesilate treated group were significantly decreased,but the activity of renal SOD,GSH-PX were increased notably.In addition,the renal pathologic changes in calcium dobesilate treated group was also improved.CONCLUSION:
Oxidative stress takes key point in the development of diabetic nephropathy,and antioxidation may be the possible mechanism of the neohroprotective action of calcium dobesilate.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2001
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS