Scanning Electron Microscopic Observation of the Protective effects of ?-receptor antagonist on the otoconia in the Rat / 听力学及言语疾病杂志

ABSTRACT

Objective To observe the protective effect of ? receptor antagonist(Vasobral) against the aging process in rats otoconia morphology.Methods 15 healthy Wistar rats were subdivided into 3 groupsNormal control( n=5 ),aging group( n=5 ) and aging plus Vasobral group( n=5 ).Results The aged otlith took the form of clew-like fusion,flattening and some giant otoconia.And there was also some sphericand strange otoconia.In the region of transitional cells,there was many otoconia phagocytosis.Some scraps of saccule lost cilia,And the otoconia in the Vasobral group appeared to be spheric and some of them adhered together,but this phenomenon was not wide-spread.No giant otoconia was found in this group.The otoconia in the transitional region was less compared with the aged group.Conclusion ? receptor antagonist(Vasobral) has the effect of protection on the aging process of the otoconia.