Simultaneous Determination of 2 Ingredients in Compound Diphenhydramine Liniment by GC / 中国药房

ABSTRACT

OBJECTIVE:To establish the method for simultaneous determination of camphor and menthol in compound diphenhydramine liniment.METHODS:The DB-WAX capillary column was used.The column temperature was increased by programming with the sample entrance and detector being at250℃.The carrier gas was nitrogen.The flow rate was1ml/min and shunting ratio was25∶1.N-octyl alcohol was used as internal standard.RESULTS:The determinable concentrations of camphor and menthol were in the linear range of0.1～1.2mg/ml(r=0.9998)and0.2～1.2mg/ml(r=0.9999)respective-ly.The average recoveries were98.78%and97.88%respectively.CONCLUSION:The established method is accurate,spe-cific and replicable,which can be applied to quality control of the liniment.