Preparation and Quality Control of the Compound Metronidazole Hollow Suppository / 中国药房
China Pharmacy
; (12)2001.
Article
em Zh
| WPRIM
| ID: wpr-524876
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WPRO
ABSTRACT
OBJECTIVE:To prepare and establish quality control for the compo und metronidazole hollow suppository.METHODS:The compound metronidazole hollow suppository was prepared with semisynthesis fatty acid glyceride as ground substance;The contents of metronidazole and ofloxacin were determined by dual-wave length K-ratio method and equivalent absorption dual-wave length method.RESULTS:The detecting concentration linear range of metronidazole and ofloxacin were6.0~18.0?g/ml and3.0~9.0?g/ml respectively,the average recovery were100.98%and99.56%(n=5)respectively,RSD were0.82%?0.80%respectively.CONCLUSION:This method is convenient,accurate and reproducible,which can be used for the quality control of compound metronidazole suppository.
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WPRIM
Idioma:
Zh
Revista:
China Pharmacy
Ano de publicação:
2001
Tipo de documento:
Article