Study on Pharmacokinetics of Escitalopram Oxalate Tablets in Human Body / 中国药房
China Pharmacy
;
(12)2001.
Artigo
em Chinês
| WPRIM
| ID: wpr-525117
ABSTRACT
OBJECTIVE:
To study the pharmacokinetics of escitalopram oxalate tablets in human body.METHODS:
Es-citalopram oxalate tablets were administered orally at a single dose of30mg to10healthy subjects respectively,the plasma concentration of escitalopram oxalate was determined by HPLC method,the pharmacokinetic parameter was fitted with3p97software.RESULTS:
The concentration-time curve of escitalopram oxalate tablets was in line with the two-compartment model,the main pharmacokinetics parameters of escitalopram oxalate were as follows,the C max was(42.73?10.19)?g?L,t max was(2.90?0.32)h,t 1/2 was(35.34?7.78)h,AUC 0~132 was(1241.5?194.3)(?g?h)/L and the AUC 0~∞ was(1327.5?210.5)(?g?h)/L.CONCLUSION:
The study on pharmacokinetics can be used as a reference in the clinical medication.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2001
Tipo de documento:
Artigo
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