Preparation and Quality Control of Compound Sparfloxacin Auristillae / 中国药房

ABSTRACT

OBJECTIVE:To prepare compound sparfloxacin auristillae and to establish its quality control method.METHODS:The auristillae was prepared with glycerin and alcohol as solvents;the contents of econazole and sparfloxacin were determined by UV spectrophotometry with their respective detection wavelengths at360nm and297nm respectively,and the stability of which were determined as well.RESULTS:The linear concentration ranges of econazole and sparfloxacin were2～400?g/ml and0.4～80?g/ml respectively;the average recovery of econazole and sparfloxacin were100.96%(RSD=0.99%)and100.38%(RSD=0.44%)respectively.The expiry date(shelf life)of the finished products was above2years.CON?CLUSIONThe preparation is simple in preparation,good in stability;and the quality control method is simple and easy,rapid,accurate and feasible.