Lymphangiogenesis in Breast Cancer Correlates with Matrix Stiffness on Shear-Wave Elastography
Yonsei Medical Journal
;
: 599-605, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-52541
ABSTRACT
PURPOSE:
To correlate tumor stiffness and lymphangiogenesis in breast cancer and to find its clinical implications. MATERIALS ANDMETHODS:
A total of 140 breast cancer patients were evaluated. Tumor stiffness was quantitatively measured by shear-wave elastography in preoperative ultrasound examination, calculated as mean elasticity value (kPa). Slides of resected breast cancer specimens were reviewed for most fibrotic area associated with tumor. D2-40 immunohistochemical staining was applied for fibrotic areas to detect the lymphatic spaces. Microlymphatic density, tumor stiffness, and clinicopathologic data were analyzed.RESULTS:
Higher elasticity value was associated with invasive size of tumor, microlymphatic density, histologic grade 3, absence of extensive intraductal component, presence of axillary lymph node metastasis, and Ki-67 labeling index (LI) in univariate regression analysis, and associated with Ki-67 LI and axillary lymph node metastasis in multivariate regression analysis. Microlymphatic density was associated histologic grade 3, mean elasticity value, and Ki-67 LI in univariate regression analysis. In multivariate regression analysis, microlymphatic density was correlated with mean elasticity value.CONCLUSION:
In breast cancer, tumor stiffness correlates with lymphangiogenesis and poor prognostic factors.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Mama
/
Neoplasias da Mama
/
Análise Multivariada
/
Análise de Regressão
/
Linfangiogênese
/
Técnicas de Imagem por Elasticidade
/
Linfonodos
/
Metástase Linfática
/
Invasividade Neoplásica
/
Estadiamento de Neoplasias
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Yonsei Medical Journal
Ano de publicação:
2016
Tipo de documento:
Artigo
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