Relationship between Carotid Artery Intima-Media Thickness Measured by Ultrasonography and Apolipoprotein E and Angiotensin Converting Enzyme Gene Polymorphisms in Diabetic Nephropathy / 대한신장학회잡지
Korean Journal of Nephrology
;
: 444-454, 2000.
Artigo
em Coreano
| WPRIM
| ID: wpr-52619
ABSTRACT
BACKGROUND:
We evaluated the distribution of the polymorphisms of apolipoprotein E and angiotensin converting enzyme gene in patients with diabetic nephropathy and also evaluated possible association between the apolipoprotein E carriers and angioten-sin converting enzyme genotypes and intima-media thickness of the common carotid artery.METHODS:
Study participants were 92 patients with diabetic nephropathy(50 men and 42 women). Hb(A1C), albuminuria, and lipid status were assessed by standard laboratory techniques ; the apolipoprotein E carriers were assessed by modified amplification refractory mutation system and the angioten-sin converting enzyme genotypes were assessed by polymerase chain reaction. The intima-media thickness was measured by high-resolution ultrasonography.RESULTS:
The apolipoprotein E frequencies of patients were E2 8%, E3 76%, and E4 16%. The intima-media thickness varied by apo E groups. E2 group has less common carotid intima-media thickness than E3 and E4 groups(p<0.05). The angiotensin converting enzyme genotypes were distributed as follows ; 35% II, 49% ID, 16% DD. The intima-media thickness value did not differ among patients with various angiotensin converting enzyme genotypes. Multiple logistic regression analysis showed that age and apolipoprotein E genotypes were determinants for the intima-media thickness.CONCLUSION:
Our results suggested that apolipoprotein E polymorphism is associated with carotid artery intima-media thickness in diabetic nephropathy. But, we could not find an association between carotid artery intima-media thickness and angiotensin converting enzyme gene polymorphism in diabetic nephropathy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Apolipoproteínas
/
Apolipoproteínas E
/
Angiotensinas
/
Artérias Carótidas
/
Modelos Logísticos
/
Reação em Cadeia da Polimerase
/
Ultrassonografia
/
Artéria Carótida Primitiva
/
Peptidil Dipeptidase A
/
Nefropatias Diabéticas
Tipo de estudo:
Estudo diagnóstico
/
Fatores de risco
Limite:
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Nephrology
Ano de publicação:
2000
Tipo de documento:
Artigo
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