Simultaneous Content Determination of Metronidazole,Tetracaine Hydrochloride and Dexamethasone Acetate in Metronidazole Compound Powder by HPLC / 中国药房
China Pharmacy
;
(12)2001.
Artigo
em Chinês
| WPRIM
| ID: wpr-527533
ABSTRACT
OBJECTIVE:
To establish HPLC method for the simultaneous content determination of metronidazole,tetra-caine hydrochloride and dexamethasone acetate in metronidazole compound.METHODS:
The content determination was per-formed on column C 18 ;the mobile phase consisted methanol-water-triethylamine(65∶35∶0.36),the detection wavelength of both metronidazole and tetracaine hydrochloride was310nm,and240nm for dexamethasone acetate,the flow rate was1ml/min and the column temperature was25℃.RESULTS:
The linear ranges of metronidazole,tetracaine hydrochloride and dexameth_ asone acetate were0.412?g~2.06?g(r=0.9999),0.191?g~0.956?g(r=0.9999)and0.121?g~0.604?g(r=0.9998),respectively,and their average recoveries were100.69%(RSD=1.28%),101.37%(RSD=0.23%)and102.40%(RSD=0.89%),respectively.CONCLUSION:
The method was simple,accurate,reproducible,and suitable for the quality control of metronidazole compound.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2001
Tipo de documento:
Artigo
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