Optimization of Formula and Preparation Technics of Gatifloxacin Dispersible Tablets / 中国药房

ABSTRACT

OBJECTIVE:To optimize the preparation technics and the formula of gatifloxacin dispersible tablets.METHODS:The adjuvant like disintegrant etc.,the formula and preparation process were optimized by a series of experi-ments.The dissolution rates of the principal agent in dispersible tablet and conventional tablet were determined and compared.RESULTS:Sodium carboxymethyl starch and crospolyvinylpyrrolidone were optimized as the disintegrants of the dispersible tablet formula;The dissolution rate of the dispersible tablet was faster than that of the conventional tablet.CONCLUSIONS:The prepared gatifloxacin dispersible tablet is reasonable in formula,feasible in technology and it meets the quality standards.