Effect and mechanism of kansui root on microcirculation of pancreatic tissues in rats with severe acute pancreatitis / 中国普通外科杂志

ABSTRACT

Objective To explore the effect and mechanism of kansui root on microcirculation of pancreatic tissues in severe acute pancreatitis(SAP) rats.Methods SD rats were randomly divided into sham group(S group),SAP group and kansui root therapy group(K group).40 rats in each group.Serum amylase,and thromboxame-B2(TXB_2),6-Keto-F_(1?)(6-Keto PGF_(1?))levels and expressions of cyclooxygenase-2(COX-2)mRNA and protein in pancreatic tissue,microscopy and election microscopy of pancreas,mortality within 72 hour after operation in each group were tested at 2h,6h,12h,and 24h after operation.Results (1)The TXB_2,6-keto PGF_(1?) levels and the ratio of TXB_2/6-Keto-PGF_(1?)(T/P) in SAP group were all(obviously) higher than those in S group(P