Effects of acute HIV-1 infection on gene expression in U937 promonocytes / 中国病理生理杂志
Chinese Journal of Pathophysiology
; (12)1989.
Article
em Zh
| WPRIM
| ID: wpr-528145
Biblioteca responsável:
WPRO
ABSTRACT
AIM: To study the effects of acute HIV-1 infection on gene expression in U937 human promonocyte for understanding the pathogenecis of AIDS. METHODS: The expression levels of 550 host cell RNA transcripts in U937 human promonocyte at 2-3 d after HIV-1 infection were assessed using cDNA microarray analysis, and the results were confirmed by semiquantitative RT-PCR. RESULTS: Our results showed that 38 genes were differentially regulated in the infected U937 cells at 2-3 d post infection: 26 genes were down-regulated and 12 genes were up-regulated. These genes encode a host of proteins with divergent functions in a variety of cellular processes including receptor-mediated signaling transduction, subcellular signal trafficking, apoptosis, transcriptional regulation, and chemotaxis. CONCLUSION: HIV-1 infection alters gene expression in U937 human promonocytes.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Pathophysiology
Ano de publicação:
1989
Tipo de documento:
Article