Impact of Allopurinol on Heart Function,Endothelial Function and Indexes of Inflammation in Patients with Acute Myocardial Infarction / 中国药房
China Pharmacy
;
(12)2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-528817
ABSTRACT
OBJECTIVE:
To observe the impact of allopurinol on heart function,endothelial function and indexes of inflammation in controlling hyperuricemia in patients with acute myocardial infarction(AMI).METHODS:
A total of 98 patients with AMI complicated with hyperuricemia were randomized to treatment group(treated with allopurinol plus alimentary control)and control group(alimentary control alone)for 6wk.Heart function,endothelial function and inflammation indexes between 2 groups before and after treatment were observed.RESULTS:
In treatment group,serum uric acid level were decreased significantly(t=2.317,P=0.046),LVEF and flow-mediated dilatation(FMD)function improved significantly(t=— 2.106,P=0.073;t=— 3.47,P=0.007),and C reactive protein level were significantly lower than in the control group(t=4.78,P=0.002).CONCLUSION:
Allopurinol can decrease hyperuricemia level,improve endothelial dysfunction,heart function and inflammatory reactions.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2005
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS