The Study on the Impact of Family History of Hypertension and Diabetes Mellitus on the Genetic Phenotype in Normoglycemic Subjects / 中国慢性病预防与控制

ABSTRACT

Objective To explore the impact of family history of hypertension and diabetes mellitus on the phenotype of insulin resistance and the ?-cell function in normoglycemic subjects. Methods 275 normoglycemic subjects were divided into four groups according to family history of hypertension and diabetes,namely group combined with family history of hypertension and diabetes (H+D+group),group without family history of hypertension and diabetes (H-D-group),group without family history of hypertension but with diabetes (H-D+group),group with family history of hypertension but without diabetes (H+D-group). The homeostasis model assessment of insulin resistance(HOMA-IR) and the function of insulin secretion (HOMA-?) was used to estimate insulin resistance and ?-cell function. Results The mean body mass index,waist to hip ratio,blood pressure,triglycerides,cholesterol and HOMA-IR were significantly higher in H+D+group than those in H-D-group,but HDL,HOMA-? were significantly lower in H+D+group than those in H-D-group (all P