Blood Concentration Monitoring of Valproic Acid: Clinical Evaluation / 中国药房

ABSTRACT

OBJECTIVE: To analyze the therapeutic drug monitoring results of valproic acid( anti- epileptic drug) . METH-ODS The concentrations of valproic acid in 226 cases in our hospital were determined by fluorescence polarization immunoassay. RESULTS: The results showed that 47. 79% were within the normal referenced concentration range, with average concentration at( 66. 19? 12. 13) ? g? mL- 1, 46. 90% were below the lower limit and 5. 31% were above the upper limit. CONCLUS-ION The monitoring results are far from satisfactory. It is advisable to adopt individualized administration so as to achieve the goal of treatment.