Clinical Efficacy of Compound Glycyrrhizin Combined with Reduced Glutathione on Patients with Alcoholic Liver Cirrhosis / 中国药房

ABSTRACT

OBJECTIVE:To observe the curative effects of compound glycyrrhizin used in combination with reduced glutahione for the treatment of alcoholic liver cirrhosis(ALC).METHODS:40 patients with ALC were randomized into the treatment group and control group.The treatment group was treated with compound glycyrrhizin 80mL and reduced glutathione 1.20g to observe the changes in hepatic function,hepatic fibrosis,clinical symptoms and therapeutic effects;whereas the control group was treated only with reduced glutathione 1.20g.The course of treatment lasted 2 weeks for both groups.RESULTS:After treatment for 2 weeks,the serum glutamic pyruvic transaminase(ALT),aspartate aminotransferase (AST),?-glutamyl transpeptidase(?-GT),total biliribin(TB),hyaluronic acid(HA),type Ⅲ procollagen(PC Ⅲ) and type Ⅳ collagen(Ⅳ-C) levels in the treatment group decreased markedly, the clinical symptoms were improved obviously,the total effective rates in the treatment group were 90% and there were significant differences in ALT, AST,?-GT,TB,HA,PC Ⅲ,Ⅳ-C levels.Cli-nical symptoms and total effective rates between treatment group and control group showed significant difference(P