Pharmacodynamics of Xuanguizhitong Drop Pill in the Treatment of Pain Caused by Qi-blood Stasis / 中国药房

ABSTRACT

OBJECTIVE:To study the pharmacodynamics of Xuanguizhitong drop pill in the treatment of pain caused by Qi-blood Stasis. METHODS: Xuanguizhitong drop pill were prepared into 3 different doses (0.25,0.5, and 1 g?kg-1) with new distilled water. The effects of Xuanguizhitong drop pill at different dose in promoting blood flow, analgesia, anti-inflammatory effect, the ability of anoxia-tolerance at ordinary pressure, and improving the hemorheology indexes in blood stasis model animals were compared. RESULTS: Xuanguizhitong drop pill were remarkable in analgesic, anti-inflammatory and anticoagulant effects and anoxia-tolerance ability at ordinary pressure.The hyperviscosity, thickness, coagulation and accumulation of blood caused by "cold accumulation" in the blood stasis syndrome model rabbits were also improved significantly by Xuanguizhitong drop pill.CONCLUSION:Xuanguizhitong drop pill has remarkable analgesic effect and can promote blood flow to a certain extent.