Septic shock down-regulates L-arginine /NOS/NO pathway of platelet and aortic intima in rats / 中国病理生理杂志

ABSTRACT

AIM: To investigate alteration and cross link of the aortic and platelet endogenous L-arginine/NOS/NO pathway induced by septic shock.METHODS: The septic shock model was made in rats by caecal ligation and puncture.NO-2 /NO-3 production released from aortic and platelet was measured with Greiss assay.NOS activity and L-arginine transport activity were detected by isotope tracer method.RESULTS: Both in early and late stage of septic shock,NO-2 /NO-3 production,NOS activity,and the L-arginine transport from the aorta intima and platelets were obviously decreased,while those of the aorta media and adventitia were obviously increased(P0.05 and P