Preparation Technology of Cefixime Suspension and the Influencing Factors of Its Sedimentation Volume Ratio / 中国药房

ABSTRACT

OBJECTIVE:To optimize the preparation technology of cefixime suspension and study its stability.METHODS:The effects of hydroxypropyl cellulose,xanthan gum and sodium lauryl sulfate in different proportions on the sedimentation volume ratios of the suspensions were investigated by orthogonal experiments to optimize the preparation technology.The stability of the preparation was studied by accelerated test.RESULTS:The optimum preparation technology for cefixime suspension was as follows:the proportions of sodium dodecylsulfate,xanthan gum,and hydroxy-propyl methyl cellulose(HPMC) were 10%,20%,and 15%,respectively.The prepared suspension had simple formula and good stability,with all indexes up to the quality specification for suspension.CONCLUSION:The suspension prepared in accordance with this formula was able to meet the requirements of Chinese Pharmacopoeia on dry suspension.