Clinical Efficacy of Fasudil Hydrochloride Injections (Administered at Different Time) for Acute Cerebral Infarction / 中国药房

ABSTRACT

OBJECTIVE:To evaluate the efficacy and safety of hydrochloric fasudil(administered at different time after onset)for acute cerebral infarction(ACI).METHODS:90 patients developed ACI within 72 h were randomly divided into trial group and control group of 45 each.The trial group was subdivided into trial group 1(developed ACI within 24 h)and trial group 2(developed ACI for more than 24 h).The control group received Compound Radix Salviae Miltiorrhizae injection for 15 days while the trial groups received Fasudil Hydrochloride for 15 days.Improvement of neurological function was evaluated using China Stroke Scales(CSS).RESULTS:The CSS of trial group 1 and trial group 2 was significantly decreased as compared with that of control group,and the CSS in trial group 1 was markedly decreased than in trial group 2,all showing significant differences(P