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Effects of rolipram on learning and memory and the activity of PDE4 in hippocampus following the focal brain injury induced by ischemia-reperfusion in rats / 中国病理生理杂志
Chinese Journal of Pathophysiology ; (12)1989.
Artigo em Chinês | WPRIM | ID: wpr-530599
ABSTRACT

AIM:

To investigate the effects of rolipram on the ability of learning and memory and the activity of PDE4 in hippocampus following the focal brain injury induced by ischemia-reperfusion in rats.

METHODS:

The cerebral ischemia-reperfusion injury model was made by middle cerebral artery occlusion(MCAO) in rats.The rats were randomly divided into sham-operated group,model group,and rolipram group.Rolipram was administered once a day(1 mg/kg,ip) from 6 h after the onset of the operation for 2 weeks.Then the learning and memory abilities were tested after Morris water maze and step-though training.The activity of PDE4 in hippocampus was evaluated by HPLC.

RESULTS:

In the Morris water maze test,compared to sham-operated group,the platform-finding time and swimming distance in model group were significantly longer(P

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo prognóstico Idioma: Chinês Revista: Chinese Journal of Pathophysiology Ano de publicação: 1989 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo prognóstico Idioma: Chinês Revista: Chinese Journal of Pathophysiology Ano de publicação: 1989 Tipo de documento: Artigo